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Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society

A decrease in the activity of thiamin-dependent enzymes limits the conversion of pyruvate to acetyl-CoA and the utilization of the citric acid cycle, leading to accumulation of pyruvate and lactate

The apparent associations observed in earlier research likely reflect confounding factors such as maternal illness, genetics, or recall bias

Essential elements include HPLC (High Performance Liquid Chromatography) purity testing showing 98% or higher purity, mass spectrometry confirming correct molecular identity, and endotoxin testing ensuring bacterial contamination remains within safe limits

J Surg Orthop Adv